Human systems biology, built to explain and intervene.
We combine deeply phenotyped cohorts, multi-omics, causal and predictive modeling, and human experimental systems to move from association toward mechanism.
AI-enabled digital twins & longitudinal multi-omics
Our longitudinal studies integrate microbiome profiles across body sites with metabolomics, lipidomics, proteomics, cytokines, clinical laboratories, physiology, exposures, and life events. We build individualized models of biological state, stability, perturbation, recovery, and disease transition.
Human immune organoids for microbiome–host mechanisms
We develop organoid systems from human tonsil and spleen—secondary lymphoid tissues that preserve key immune interactions—to test how microbial strains, peptidoglycan fragments, antigens, and therapeutic perturbations influence immune organization and function.
Inflammation, pulmonary vascular disease & precision medicine
We use single-cell transcriptomics, immunomics, metabolomics, lipidomics, and microbiome profiling to define disease mechanisms in pulmonary arterial hypertension and other chronic inflammatory conditions. Current work examines oral–systemic microbial signals, HERV-K-associated immunity, and actionable inflammatory endotypes.
Work across disciplines and institutions.
Our programs are designed for collaboration among clinicians, cohort scientists, computational researchers, immunologists, microbiologists, and translational partners.
Clinical cohorts
Integrate longitudinal biospecimens, phenotypes, and outcomes into mechanistic multi-omics studies.
Methods & computation
Develop statistical, causal, and AI methods that remain interpretable and experimentally testable.
Translation
Advance biomarkers, organoid platforms, and intervention concepts toward practical health impact.
Bring a question, cohort, or technology.
We welcome collaborations that connect human variation with testable biology.