Selected Publications
Authorship color key — Xin Zhou is highlighted by role in each publication.
● Corresponding author● First / co-first author● Participant author
2026 · Science
Autonomous biomedical research with an artificial intelligence agent
Kexin Huang, Serena Zhang, Hanchen Wang, Yuanhao Qu, Yingzhou Lu, Ryan Li, Yusuf Roohani, Lin Qiu, Shiyi Cao, Gavin Li, Junze Zhang, Di Yin, Rick Wierenga, Deniz Kavi, Sherry Liu, Tianwei She, Shruti Marwaha, Jennefer N Carter, Xin Zhou, Matthew T Wheeler, Jonathan A Bernstein, Mengdi Wang, Peng He, Jingtian Zhou, Michael P Snyder, Le Cong, Aviv Regev, Jure Leskovec
Science. 2026 Jul 9:eadz4351. doi: 10.1126/science.adz4351. Online ahead of print.
Participant author · Publication 39
2026 · The Lancet Microbe
From microbiomes to predictive ecosystems: challenges and opportunities in artificial intelligence-based approaches
Wanqian Yu, Hua Qu, Shaopu Wang, Mang Shi, Yingzhou Lu, Shuting Xia, Catherine Stanton, Chenhong Zhang, Yuhao Wang, Tongyu Zhu, Dong Zhu, Xin Zhou, R Paul Ross, Zhemin Zhou, Yuan Huang
The Lancet Microbe. Online ahead of publication: j.lanmic.2026.101428.
Corresponding author · Publication 38
2026 · Med
Power and Sample Size Estimation in Human Microbiome Research
Qianyi Zhou, Yingzhou Lu, Luman Wang, Wei Zhou, Haley Oba, Yanjiao Zhou, Minjie Shen, Xiaodong Qu, Cristabelle De Souza, Andre Rayner, Yanfei Chen, Tess Y. Cheng, Zongxin Ling, Lanjuan Li, Chang Liu, Anita Y. Voigt, Ruoyun Xiong, Julia Oh, Daniel Spakowicz, Caroline Dravillas, Amy Wen Tian, Mark R. Nicolls, Amber-Thy Huynh, Xin Chen, Jiyuan Hu, Mingguang He, Fuchu He, Michael P. Snyder, Jing Yang, Xin Zhou
Med. In Press.
Corresponding author · Publication 37
2026 · Molecular Omics
A practical guide to experimental design and power analysis for metaproteomics studies
Luman Wang, Qianyi Zhou, Yutong Li, Feng Sun, Xin Zhou, Leyuan Li
Molecular Omics. 22(2):aaiag014.
Corresponding author · Publication 36
2026 · Microbiome
Cross-body site microbial interactions influence the human plasma metabolome
Jingxiang Zhang, Chao Jiang, Xin Zhou, Peng Gao, Sunny Wong, Michael Snyder, Xiaotao Shen
Microbiome. Online Ahead of Press.
Participant author · Publication 35
2025 · Respiratory Research
Altered maturation and activation state of circulating monocytes is associated with their enhanced recruitment in pulmonary arterial hypertension
Rebecca L. Harper, Xin Zhou, David P. Marciano, Aiqin Cao, Lingli Wang, Guibin Chen, Mir S. Adil, Wenyu Zhou, Peter Maguire, Shanthi Deivanayagam, Quan Yu, Vignesh Viswanathan, Dan Yang, Marcy Martin, Sarasa Isobe, Shoichiro Otsuki, Jordan Burgess, Audrey Inglis, Devon Kelley, Patricia A. del Rosario, Andrew Hsi, Francois Haddad, Roham T. Zamanian, Manfred Boehm, Michael P. Snyder, Marlene Rabinovitch
Respiratory Research. 26:148.
First / co-first author · Publication 34
2025 · Acta Pharmaceutica Sinica B
Unlocking the healthy human microbiome: Redefining core microbial signatures
Shuting Xia, Diya Jiang, Qianyi Zhou, Hairong Lyu, Anita Y. Voigt, Xin Zhou, Zhemin Zhou, Yuan Huang
Acta Pharmaceutica Sinica B. 15(2):1189.
Corresponding author · Publication 33
2025 · Communications Medicine
Achieving inclusive healthcare through integrating education and research with AI and personalized curricula
Amir Bahmani, Kexin Cha, Arash Alavi, Amit Dixit, Antony Ross, Ryan Park, Francesca Goncalves, Shirley Ma, Paul Saxman, Ramesh Nair, Ramin Akhavan-Sarraf, Xin Zhou, Meng Wang, Kévin Contrepois, Jennifer Li-Pook-Than, Emma Monte, David Jose Florez Rodriguez, Jaslene Lai, Mohan Babu, Abtin Tondar, Sophia Miryam Schüssler-Fiorenza Rose, Ilya Akbari, Xinyue Zhang, Kritika Yegnashankaran, Joseph Yracheta, Kali Dale, Alison Derbenwick Miller, Scott Edmiston, Eva M. McGhee, Camille Nebeker, Joseph C. Wu, Anshul Kundaje, Michael P. Snyder
Communications Medicine. 5:356.
Participant author · Publication 32
2025 · Research
Microbiome–Immune Interaction in Pulmonary Arterial Hypertension: What Have We Missed?
Xin Zhou, Wen Tian, Shenbiao Gu, Marlene Rabinovitch, Mark R. Nicolls, Michael P. Snyder
Research. 8:0669. Review.
First / co-first author · Publication 31
2025 · Frontiers in Immunology
Harnessing the human gut microbiota: an emerging frontier in combatting multidrug-resistant bacteria
Wenwen Ding, Yiwen Cheng, Xia Liu, Zhangcheng Zhu, Lingbin Wu, Jie Gao, Wenhui Lei, Yating Li, Xin Zhou, Jian Wu, Yongtao Gao, Zongxin Ling, Ruilai Jiang
Frontiers in Immunology. 16:1563450. Review.
Participant author · Publication 30
2025 · Phenomics
Embracing interpersonal variability of microbiome in precision medicine
Xin Zhou, Xin Chen, Mark M. Davis, Michael P. Snyder
Phenomics. 1–6. Review.
First / co-first author · Publication 29
2025 · Briefings in Bioinformatics
The iPhylo suite: an interactive platform for building and annotating biological and chemical taxonomic trees
Yueer Li, Chen Peng, Fei Chi, Zinuo Huang, Mengyi Yuan, Xin Zhou, Chao Jiang
Briefings in Bioinformatics. 26(1):bbae679.
Participant author · Publication 28
2024 · Brain Behavior & Immunity
Human Gut Microbiome and Immune Dynamics During an Immersive Psychosocial Therapeutic Program
Xin Zhou, Ariel B. Ganz, Andre Rayner, Tess Yan Cheng, Haley Oba, Benjamin Rolnik, Samuel Lancaster, Xinrui Lu, Yizhou Li, Jethro S. Johnson, Rebecca Hoyd, Daniel J. Spakowicz, George M. Slavich, Michael P. Snyder
Brain Behavior & Immunity. 17(125):428–443.
First / co-first author · Publication 27
2025 · Nature Aging
Nonlinear dynamics of multi-omics profiles during human aging
Xiaotao Shen, Chuchu Wang, Xin Zhou, Wenyu Zhou, Daniel Hornburg, Si Wu, Michael P. Snyder
Nature Aging. 4:1619–1634.
Participant author · Publication 26
2024 · Cell Host & Microbe
Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and diseases
Xin Zhou, Xiaotao Shen, Jethro S. Johnson, Daniel J. Spakowicz, Melissa Agnello, Wenyu Zhou, Monica Avina, Alexander Honkala, Faye Chleilat, Shirley Jingyi Chen, Kexin Cha, Shana Leopold, Chenchen Zhu, Lei Chen, Lin Lyu, Daniel Hornburg, Si Wu, Xinyue Zhang, Chao Jiang, Liuyiqi Jiang, Lihua Jiang, Ruiqi Jian, Andrew W. Brooks, Meng Wang, Kévin Contrepois, Peng Gao, Sophia Miryam Schüssler-Fiorenza Rose, Thi Dong Binh Tran, Hoan Nguyen, Alessandra Celli, Bo-Young Hong, Eddy J. Bautista, Yair Dorsett, Paula Kavathas, Yanjiao Zhou, Erica Sodergren, George M. Weinstock, Michael P. Snyder
Cell Host & Microbe. 32:1–21.
First / co-first author · Publication 25
2023 · Nature Metabolism
Dynamic lipidome alterations associated with human health, disease and ageing
Daniel Hornburg, Si Wu, Mahdi Moqri, Xin Zhou, Kevin Contrepois, Nasim Bararpour, Gavin M. Traber, Baolong Su, Ahmed A. Metwally, Monica Avina, Wenyu Zhou, Jessalyn M. Ubellacker, Tejaswini Mishra, Sophia Miryam Schüssler-Fiorenza Rose, Paula B. Kavathas, Kevin J. Williams, Michael P. Snyder
Nature Metabolism. 5(9):1578–1594.
Participant author · Publication 24
2023 · Advanced Gut & Microbiome Research
The roles and mechanisms of gut microbiota in food allergy
Yiwen Cheng, Xia Liu, Feng Chen, Benjamin M. Rolnik, Xin Chen, Faye Chleilat, Zongxin Ling, Michael P. Snyder, Xin Zhou
Advanced Gut & Microbiome Research. 2023:16. Review.
Corresponding author · Publication 23
2023 · Genome Research
Simultaneous Profiling of Host Expression and Microbial Abundance by Spatial Meta Transcriptome Sequencing
Lin Lyu, Xue Li, Ru Feng, Xin Zhou, Xiaofei Yu, Guo Qiang Chen, Yufeng Yao, Tuhin K. Guha, Bing Su, Duowu Zou, Michael P. Snyder, Lei Chen
Genome Research. 33(3):401–411.
First / co-first author · Publication 22
2022 · BMC Microbiology
Gut microbiota analyses of Saudi populations for type 2 diabetes-related phenotypes reveals significant association
Fahad A. Al-Muhanna, Alexa K. Dowdell, Abdulmohsen H. Al Eleq, Waleed I. Albaker, Andrew W. Brooks, Ali I. Al-Sultan, Abdullah M. Al-Rubaish, Khaled R. Alkharsah, Raed M. Sulaiman, Abdulaziz A. Al-Quorain, Cyril Cyrus, Rudaynah A. Alali, Chittibabu Vatte, Fred L. Robinson, Xin Zhou, Michael P. Snyder, Afnan F. Almuhanna, Brendan J. Keating, Brian D. Piening, Amein K. Al-Ali
BMC Microbiology. 22(1):301.
Participant author · Publication 21
2022 · Frontiers in Aging
Exploratory studies of oral and fecal microbiome in healthy human aging
Xin Zhou, Baohong Wang, Patrick C. Demkowicz, Jethro S. Johnson, Yanfei Chen, Dan Spakowicz, Yanjiao Zhou, Yair Dorsett, Lei Chen, Erica Sodergren, George A. Kuchel, George Weinstock
Frontiers in Aging. 3:1002405.
Corresponding author · Publication 20
2022 · Circulation Research
Defect of KMT2D-mediated NOTCH Signaling Contributed to the Coronary Arterial Abnormalities in Hypoplastic Left Heart Syndrome
Zhiyun Yu, Xin Zhou, Ziyi Liu, Victor Pastrana-Gomez, Yu Liu, Minzhe Guo, Lei Tian, Timothy J. Nelson, Nian Wang, Seema Mital, David Chitayat, Joseph C. Wu, Marlene Rabinovitch, Sean M. Wu, Michael P. Snyder, Yifei Miao, Mingxia Gu
Circulation Research. 131(3):280–282.
First / co-first author · Publication 19
2022 · Genome Research
Precision environmental health monitoring by longitudinal exposome and multi-omics profiling
Peng Gao, Xiaotao Shen, Xinyue Zhang, Chao Jiang, Sai Zhang, Xin Zhou, Sophia Miryam Schüssler-Fiorenza Rose, Michael Snyder
Genome Research. 32(6):1199–1214.
Participant author · Publication 18
2022 · Clinical and Translational Medicine
Exploring disease interrelationships in patients with lymphatic disorders: A single center retrospective experience
Stanley G. Rockson, Xin Zhou, Lan Zhao, Davood K. Hosseini, Xinguo Jiang, Andrew J. Sweatt, Dongeon Kim, Wen Tian, Michael P. Snyder, Mark R. Nicolls
Clinical and Translational Medicine. 12(4):e760.
First / co-first author · Publication 17
2021 · Infectious Microbes & Diseases
The Impact of SARS-CoV-2 on the Human Immune System and Microbiome
Chuxi Wang, Xin Zhou, Meng Wang, Xin Chen
Infectious Microbes & Diseases. 3(1):14–21. Review.
Participant author · Publication 16
2020 · Diabetes
Longitudinal modeling of gut microbial abundance and serum cytokine levels links Clostridia with Th17 cell activity in humans at risk for Type 2 diabetes
Xin Zhou, Jethro S. Johnson, Daniel J. Spakowicz, Wenyu Zhou, Yanjiao Zhou, Erica Sodergren, Michael Snyder, George Weinstock
Diabetes. 69(8):1833–1842.
First / co-first author · Publication 15
2019 · BMC Microbiology
Composition and predictive functional analysis of bacterial communities inhabiting Chinese Cordyceps insight into conserved core microbiome
Fei Xia, Xin Zhou, Yan Liu, Yuling Li, Xiaohui Bai, Xuanwei Zhou
BMC Microbiology. 19(1):105.
First / co-first author · Publication 14
2019 · Scientific Reports
New statistical method identifies cytokines that distinguish stool microbiomes
Dake Yang, Jethro Johnson, Xin Zhou, Elena Deych, Berkley Shands, Blake Hanson, Erica Sodergren, George Weinstock, Bill Shannon
Scientific Reports. 9:20082.
First / co-first author · Publication 13
2019 · Nature
Longitudinal multi-omics of host–microbe dynamics in prediabetes
Wenyu Zhou, M. Reza Sailani, Kévin Contrepois, Yanjiao Zhou, Sara Ahadi, Shana R. Leopold, Martin J. Zhang, Varsha Rao, Monika Avina, Tejaswini Mishra, Jethro Johnson, Brittany Lee-McMullen, Songjie Chen, Ahmed A. Metwally, Thi Dong Binh Tran, Hoan Nguyen, Xin Zhou, Brandon Albright, Bo-Young Hong, Lauren Petersen, Eddy Bautista, Blake Hanson, Lei Chen, Daniel Spakowicz, Amir Bahmani, Denis Salins, Benjamin Leopold, Melanie Ashland, Orit Dagan-Rosenfeld, Shannon Rego, Patricia Limcaoco, Elizabeth Colbert, Candice Allister, Dalia Perelman, Colleen Craig, Eric Wei, Hassan Chaib, Daniel Hornburg, Jessilyn Dunn, Liang Liang, Sophia Miryam Schüssler-Fiorenza Rose, Kim Kukurba, Brian Piening, Hannes Rost, David Tse, Tracey McLaughlin, Erica Sodergren, George M. Weinstock, Michael Snyder
Nature. 569(7758):663–671.
Participant author · Publication 12
2019 · Endocrine Research
Estradiol Alters Hippocampal Gene Expression during the Estrous Cycle
Javed Iqbal, Zhi-Nei Tan, Min-Xing Li, Hui-Bin Chen, Boyu Ma, Xin Zhou, Xin-Ming Ma
Endocrine Research. 45(2):84–104.
Participant author · Publication 11
Publications before 2019 (10)
2017 · Gastroenterology
Similar Bacterial Signatures in Intestinal Tissues, Milk, and Dendritic Cells of Lactating Mice Suggest a Possible Entero-Mammary Pathway
Xin Zhou, Anita Voigt, Sara Paveglio, George Weinstock, Adam Matson, Zev Davidovics
Gastroenterology. 152(5):S172. Conference Proceedings.
First / co-first author · Publication 10
2017 · Frontiers in Immunology
Impact of influenza infection on the mouse gut microbiome in the context of varying diets and ages
Jenna M. Bartley, Xin Zhou, George A. Kuchel, George M. Weinstock, Laura Haynes
Frontiers in Immunology. 8:1164.
First / co-first author · Publication 9
2015 · ACS Biomaterials Science & Engineering
Tropism of CPMV to Professional Antigen Presenting Cells Enables a Platform to Eliminate Chronic Infections
Amy M. Wen, Nga Le, Xin Zhou, Nicole F. Steinmetz, Daniel L. Popkin
ACS Biomaterials Science & Engineering. 1(11):1050–1054.
Participant author · Publication 8
2015 · The American Journal of Dermatopathology
Langerhans Cell Hyperplasia from Molluscum Contagiosum
Alyn Hatter, Xin Zhou, Kord Honda, Daniel L. Popkin
The American Journal of Dermatopathology. 37(8):e93–e95.
Participant author · Publication 7
2013 · PLoS ONE
JcLEA, a novel LEA like protein from Jatropha curcas, confers high tolerance to dehydration and salinity in Arabidopsis thaliana
Jing Liang, Mingqi Zhou, Xin Zhou, Yuanjie Jin, Ming Xu, Juan Lin
PLoS ONE. 8(12):e83056.
Participant author · Publication 6
2012 · Viruses
Role of Lymphocytic Choriomeningitis Virus (LCMV) in Understanding Viral Immunology: Past, Present and Future
Xin Zhou, Srividya Ramachandran, Margaret Mann, Daniel L. Popkin
Viruses. 4:2650–2669. Review.
First / co-first author · Publication 5
2010 · International Journal of Medicinal Mushrooms
Hepatoma Cell Growth Inhibition by Inducing Apoptosis with Polysaccharide Isolated from Turkey Tail Medicinal Mushroom, Trametes versicolor (L.: Fr.) Lloyd
Xingzhong Cai, Yan Pi, Xin Zhou, Shouyi Qiao, Juan Lin
International Journal of Medicinal Mushrooms. 12(3):257–263.
Participant author · Publication 4
2010 · Preparative Biochemistry and Biotechnology
Purification and characterization of curcin, a toxic lectin from the seed of Jatropha curcas
Juan Lin, Xin Zhou, Jinya Wang, Peihong Jiang, Kexuan Tang
Preparative Biochemistry and Biotechnology. 40(2):107–118.
Participant author · Publication 3
2010 · African Journal of Biotechnology
Molecular cloning and functional analysis of the gene encoding geranylgeranyl diphosphate synthase from Jatropha curcas
Juan Lin, Yuanjie Jin, Xin Zhou, Jinya Wang
African Journal of Biotechnology. 9(23):3342–3351.
Participant author · Publication 2
2009 · African Journal of Biotechnology
AFLP analysis of genetic diversity in main cultivated strains of Ganoderma spp.
Sanqiao Wu, Xinbo Guo, Xin Zhou, Xinsheng Li, Yiyuan Chen, Juan Lin
African Journal of Biotechnology. 8(15):3448–3454.
Participant author · Publication 1